Synthesis and biological evaluation of 2-substituted-4-(3′, 4′, 5′-trimethoxyphenyl)-5-aryl thiazoles as anticancer agents
Antitumor agents that bind to tubulin and disrupt microtubule dynamics have attracted
considerable attention in the last few years. To extend our knowledge of the thiazole ring as
a suitable mimic for the cis-olefin present in combretastatin A-4, we fixed the 3, 4, 5-
trimethoxyphenyl at the C4-position of the thiazole core. We found that the substituents at the
C2-and C5-positions had a profound effect on antiproliferative activity. Comparing
compounds with the same substituents at the C5-position of the thiazole ring, the moiety at …
considerable attention in the last few years. To extend our knowledge of the thiazole ring as
a suitable mimic for the cis-olefin present in combretastatin A-4, we fixed the 3, 4, 5-
trimethoxyphenyl at the C4-position of the thiazole core. We found that the substituents at the
C2-and C5-positions had a profound effect on antiproliferative activity. Comparing
compounds with the same substituents at the C5-position of the thiazole ring, the moiety at …
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